Affiliation:
1. College of First Clinical Medicine Shandong University of Traditional Chinese Medicine Jinan China
2. College of Traditional Chinese Medicine Weifang Medical University Weifang China
3. Department of Oncology Linyi People's Hospital Linyi China
4. Department of Oncology Weifang Traditional Chinese Hospital Weifang China
Abstract
Angiogenesis is the process by which new blood vessels form and is required for tumour growth and metastasis. It helps in supplying oxygen and nutrients to tumour cells and plays a crucial role in the local progression and distant metastasis of, and development of treatment resistance in, breast cancer. Tumour angiogenesis is currently regarded as a critical therapeutic target; however, anti‐angiogenic therapy for breast cancer fails to produce satisfactory results, owing to issues such as inconsistent efficacy and significant adverse reactions. As a result, new anti‐angiogenic drugs are urgently needed. Flavonoids, a class of natural compounds found in many foods, are inexpensive, widely available, and exhibit a broad range of biological activities, low toxicity, and favourable safety profiles. Several studies find that various flavonoids inhibit angiogenesis in breast cancer, indicating great therapeutic potential. In this review, we summarize the role of angiogenesis in breast cancer and the potential of natural flavonoids as anti‐angiogenic agents for breast cancer treatment. We discuss the value and significance of nanotechnology for improving flavonoid absorption and utilization and anti‐angiogenic effects, as well as the challenges of using natural flavonoids as drugs.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Cited by
1 articles.
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