Minimal factor XIII activity level to prevent major spontaneous bleeds

Author:

Menegatti M.1,Palla R.1,Boscarino M.2,Bucciarelli P.2,Muszbek L.3,Katona E.3,Makris M.4,Peyvandi F.5ORCID,

Affiliation:

1. Department of Pathophysiology and Transplantation; Università degli Studi di Milano and Luigi Villa Foundation; Milan Italy

2. Angelo Bianchi Bonomi Hemophilia and Thrombosis Center; Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico; Milan Italy

3. Division of Clinical Laboratory Science; Faculty of Medicine; University of Debrecen; Debrecen Hungary

4. Sheffield Haemophilia and Thrombosis Centre; Sheffield UK

5. Angelo Bianchi Bonomi Haemophilia and Thrombosis Center; Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico; and Department of Pathophysiology and Transplantation; Università degli Studi di Milano; Milan Itlay

Funder

Bayer

Biotest

BPL

CSL Behring

Grifols

Kedrion

LFB

NovoNordisk

Octapharma

Pfizer

Shire

SOBI

European Association for Haemophilia and Allied Disorders

Publisher

Wiley

Subject

Hematology

Reference31 articles.

1. Factor XIII: a coagulation factor with multiple plasmatic and cellular functions;Muszbek;Phys Rev,2011

2. Molecular mechanisms affecting fibrin structure and stability;Lord;Arterioscler Thromb Vasc Biol,2011

3. The antifibrinolytic function of factor XIII is exclusively expressed through alpha(2)-antiplasmin cross-linking;Fraser;Blood,2011

4. Impaired wound healing in factor XIII deficient mice;Inbal;Thromb Haemost,2005

5. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis;Muszbek;Cardiovasc Hematol Agents Med Chem,2008

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