Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity

Author:

Fager A. M.12ORCID,Machlus K. R.3,Ezban M.4,Hoffman M.25ORCID

Affiliation:

1. Division of Hematology; Department of Medicine; Duke University School of Medicine; Durham NC USA

2. Pathology and Laboratory Medicine Service; Durham Veterans Affairs Medical Center; Durham NC USA

3. Division of Hematology; Department of Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston MA USA

4. Pharmacology; Novo Nordisk A/S; Måløv Denmark

5. Department of Pathology; Duke University School of Medicine; Durham NC USA

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

American Heart Association

Bayer

U.S. Department of Veterans Affairs

Publisher

Wiley

Subject

Hematology

Reference75 articles.

1. Modern haemophilia care;Berntorp;Lancet,2012

2. How we treat a hemophilia A patient with a factor VIII inhibitor;Kempton;Blood,2009

3. Human platelets do not express tissue factor;Osterud;Thromb Res,2013

4. A possible mechanism of action of activated factor VII independent of tissue factor;Monroe;Blood Coagul Fibrinolysis,1998

5. Pharmacological concentrations of recombinant factor VIIa restore hemostasis independent of tissue factor in antibody-induced hemophilia mice;Keshava;J Thromb Haemost,2016

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