Affiliation:
1. Department of Molecular Medicine Cornell University Ithaca New York USA
2. Molecular Control and Genetics Section, RNA Biology Laboratory National Cancer Institute at Frederick, National Institutes of Health Frederick Maryland USA
Abstract
AbstractOvercoming lysogenization defect (OLD) proteins are a conserved family of ATP‐powered nucleases that function in anti‐phage defense. Recent bioinformatic, genetic, and crystallographic studies have yielded new insights into the structure, function, and evolution of these enzymes. Here we review these developments and propose a new classification scheme to categorize OLD homologs that relies on gene neighborhoods, biochemical properties, domain organization, and catalytic machinery. This taxonomy reveals important similarities and differences between family members and provides a blueprint to contextualize future in vivo and in vitro findings. We also detail how OLD nucleases are related to PARIS and Septu anti‐phage defense systems and discuss important mechanistic questions that remain unanswered.
Funder
National Cancer Institute
National Institute of General Medical Sciences
Subject
Molecular Biology,Microbiology
Cited by
3 articles.
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