A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction-Reference-Cited by-同舟云学术

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A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction

Published:2013-05-20 Issue:6 Volume:75 Page:1536-1540
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Br J Clin Pharmacol

Author:

Mårde Arrhén Yvonne¹,Nylén Hanna²,Lövgren-Sandblom Anita²,Kanebratt Kajsa P.³,Wide Katarina⁴,Diczfalusy Ulf²

Affiliation:

1. Clinical Chemistry; Karolinska University Hospital; Huddinge; Sweden

2. Department of Laboratory Medicine; Karolinska Institutet; Huddinge; Sweden

3. CVGI iMed DMPK; AstraZeneca R&D; Mölndal; Sweden

4. Department of CLINTEC; Karolinska Institutet; Huddinge; Sweden

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.12016/fullpdf

Reference7 articles.

1. Antiepileptic drugs increase plasma levels of 4β-hydroxycholesterol in humans. Evidence for involvement of cytochrome P450 3A4;Bodin;J Biol Chem,2001

2. 4β-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians;Diczfalusy;Pharmacogenet Genom,2008

3. Urinary 6β-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals;Galteau;Eur J Clin Pharmacol,2003

4. Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo;Peng;Clin Pharmacol Ther,2011

5. Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4β-hydroxycholesterol;Kanebratt;Clin Pharmacol Ther,2008

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