Drugs targeting CTGF in the treatment of pulmonary fibrosis

Author:

Qiu Yudan12,Que Yueyue12,Ding Zheyu12,Zhang Shanshan12,Wei Rong12,Xia Jianing12,Lin Yingying12ORCID

Affiliation:

1. School of Pharmacy Hangzhou Normal University Hangzhou Zhejiang China

2. Key Laboratory of Elemene Class Anti‐Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal University Hangzhou Zhejiang China

Abstract

AbstractPulmonary fibrosis represents the final alteration seen in a wide variety of lung disorders characterized by increased fibroblast activity and the accumulation of substantial amounts of extracellular matrix, along with inflammatory damage and the breakdown of tissue architecture. This condition is marked by a significant mortality rate and a lack of effective treatments. The depositing of an excessive quantity of extracellular matrix protein follows the damage to lung capillaries and alveolar epithelial cells, leading to pulmonary fibrosis and irreversible damage to lung function. It has been proposed that the connective tissue growth factor (CTGF) plays a critical role in the advancement of pulmonary fibrosis by enhancing the accumulation of the extracellular matrix and exacerbating fibrosis. In this context, the significance of CTGF in pulmonary fibrosis is examined, and a summary of the development of drugs targeting CTGF for the treatment of pulmonary fibrosis is provided.

Publisher

Wiley

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