Ultra‐long‐acting insulin degludec has a flat and stable glucose‐lowering effect in type 2 diabetes

Author:

Heise T.1,Nosek L.1,Bøttcher S. G.2,Hastrup H.2,Haahr H.2

Affiliation:

1. Profil Institute for Metabolic Research Neuss Germany

2. Novo Nordisk A/S Søborg Denmark

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference21 articles.

1. Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies

2. Insulin degludec is a new generation ultra‐long acting basal insulin with a unique mechanism of protraction based on multi‐hexamer formation;Jonassen I;Diabetes,2010

3. Multi‐hexamer formation is the underlying basis for the ultra‐long glucose‐lowering effect of insulin degludec;Kurtzhals P;Diabetologia,2011

4. Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

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