Preterm birth in the Nordic countries—Capacity, management and outcome in neonatal care

Author:

Norman Mikael12ORCID,Padkær Petersen Jesper34,Stensvold Hans Jørgen5,Thorkelsson Thordur6,Helenius Kjell78ORCID,Brix Andersson Charlotte39,Ørum Cueto Heidi3,Domellöf Magnus10,Gissler Mika11,Heino Anna11,Håkansson Stellan10,Jonsson Baldvin212,Klingenberg Claus1314ORCID,Lehtonen Liisa78,Metsäranta Marjo15,Rønnestad Arild E.516,Trautner Simon317

Affiliation:

1. Department of Clinical Science, Intervention and Technology Karolinska Institutet Stockholm Sweden

2. Department of Neonatal Medicine Karolinska University Hospital Stockholm Sweden

3. The Danish Clinical Quality Program – National Clinical Registries (RKKP) Aarhus Denmark

4. Department of Paediatrics Aarhus University Hospital Aarhus Denmark

5. Department of Neonatal Intensive Care, Clinic of Paediatric and Adolescent Medicine Oslo University Hospital Oslo Norway

6. Department of Neonatal Medicine, Children's Hospital Iceland Landspitali University Hospital Reykjavík Iceland

7. Department of Paediatrics and Adolescent Medicine Turku University Hospital Turku Finland

8. Department of Clinical Medicine University of Turku Turku Finland

9. Department of Obstetrics and Gynaecology Aalborg University Hospital Thisted Denmark

10. Department of Clinical Sciences, Paediatrics Umeå University Umeå Sweden

11. Department of Knowledge Brokers THL Finnish Institute for Health and Welfare Helsinki Finland

12. Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden

13. Paediatric Research Group, Faculty of Health Sciences UiT‐The Arctic University of Norway Tromsø Norway

14. Department of Paediatrics and Adolescence Medicine University Hospital of North Norway Tromsø Norway

15. Department of Paediatrics, New Children's Hospital, Paediatric Research Center University of Helsinki and Helsinki University Hospital Helsinki Finland

16. Medical Faculty, Institute for Clinical Medicine University of Oslo Oslo Norway

17. Department of Intensive Care of Newborns and Small Children University Hospital of Copenhagen Copenhagen Denmark

Abstract

AbstractAimOrganisation of care, perinatal and neonatal management of very preterm infants in the Nordic regions were hypothesised to vary significantly. The aim of this observational study was to test this hypothesis.MethodsInformation on preterm infants in the 21 greater healthcare regions of Denmark, Finland, Iceland, Norway and Sweden was gathered from national registers in 2021. Preterm birth rates, case‐mix, perinatal interventions, neonatal morbidity and survival to hospital discharge in very (<32 weeks) and extremely preterm infants (<28 weeks of gestational age) were compared.ResultsOut of 287 642 infants born alive, 16 567 (5.8%) were preterm, 2389 (0.83%) very preterm and 800 (0.28%) were extremely preterm. In very preterm infants, exposure to antenatal corticosteroids varied from 85% to 98%, live births occurring at regional centres from 48% to 100%, surfactant treatment from 28% to 69% and use of mechanical ventilation varied from 13% to 77% (p < 0.05 for all comparisons). Significant regional variations within and between countries were also seen in capacity in neonatal care, case‐mix and number of admissions, whereas there were no statistically significant differences in survival or major neonatal morbidities.ConclusionManagement of very preterm infants exhibited significant regional variations in the Nordic countries.

Publisher

Wiley

Subject

General Medicine,Pediatrics, Perinatology and Child Health

Reference30 articles.

1. Declines in stillbirth and neonatal mortality rates in Europe between 2004 and 2010: results from the Euro-Peristat project

2. HeinoAGM.Nordic Perinatal Statistics 2020 (THL – Statistical Report 11/2022). Accessed October 5 2022.www.thl.fi/statistics/nordiccountriesperinatalstatistics.

3. THE European Perinatal Health Report 2015‐2019. Accessed Febraury 10 2023.https://www.europeristat.com/index.php/reports/ephr‐2019.html.

4. Geographical differences in preterm delivery rates in Sweden: A population‐based cohort study

5. Variability in Very Preterm Stillbirth and In-Hospital Mortality Across Europe

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