The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures

Author:

Feinstein Douglas L.12,Akpa Belinda S.3,Ayee Manuela A.4,Boullerne Anne I.12,Braun David1,Brodsky Sergey V.5,Gidalevitz David6,Hauck Zane7,Kalinin Sergey1,Kowal Kathy1,Kuzmenko Ivan8,Lis Kinga1,Marangoni Natalia1,Martynowycz Michael W.68,Rubinstein Israel14,van Breemen Richard1,Ware Kyle5,Weinberg Guy12

Affiliation:

1. Department of Anesthesiology; University of Illinois; Chicago Illinois

2. Jesse Brown VA Medical Center; Chicago Illinois

3. Department of Molecular Biomedical Sciences; North Carolina State University; Raleigh North Carolina

4. Department of Medicine; University of Illinois; Chicago Illinois

5. Department of Pathology; the Ohio State University; Columbus Ohio

6. Department of Physics and the Center for the Molecular Study of Condensed Soft Matter; Illinois Institute of Technology; Chicago Illinois

7. Department of Medicinal Chemistry and Pharmacognosy; University of Illinois; Chicago Illinois

8. X-ray Science Division; Argonne National Laboratory; Lemont Illinois

Funder

National Institutes of Health

Publisher

Wiley

Subject

History and Philosophy of Science,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Reference86 articles.

1. History of drugs for thrombotic disease. Discovery, development, and directions for the future;Mueller;Circulation,1994

2. The story of the discovery of heparin and warfarin;Wardrop;Br. J. Haematol,2008

3. Studies on the hemorrhagic sweet clover disease: V. Identification and synthesis of the hemorrhagic agent;Stahman;J. Biol. Chem,1941

4. Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition;Whitlon;Biochemistry,1978

5. Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle;Oldenburg;Antioxid. Redox Signal,2006

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