Perpetrator effects of ciclosporin (P‐glycoprotein inhibitor) and its combination with fluconazole (CYP3A inhibitor) on the pharmacokinetics of rivaroxaban in healthy volunteers

Author:

Brings Antonia1,Lehmann Marie‐Louise1,Foerster Kathrin I.1,Burhenne Jürgen1,Weiss Johanna1ORCID,Haefeli Walter E.1ORCID,Czock David1ORCID

Affiliation:

1. Department of Clinical Pharmacology and PharmacoepidemiologyUniversity of Heidelberg Heidelberg Germany

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference41 articles.

1. Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects

2. Rivaroxaban and macitentan can be coadministered without dose adjustment but the combination of rivaroxaban and St John's wort should be avoided

3. EMA summary of product characteristics last updatedJuly 2018(http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000944/human_med_001155.jsp&murl=menus/medicines/medicines.jsp&mid=WC0b01ac058001d125. Accessed 3 September 2018.

4. FDA drug label of Xarelto last updated February2017.https://dailymed.nlm.nih.gov/dailymed/. Accessed 3 September 2018.

5. In Vivo CYP3A Activity Is Significantly Lower in Cyclosporine-Treated as Compared With Tacrolimus-Treated Renal Allograft Recipients

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