Long‐term outcomes, quality of life, and costs of treatment modalities for T1–T2 lip carcinomas

Author:

van Hof Kira S.1ORCID,Wakkee Marlies2,Sewnaik Aniel1,Herkendaal Aimée F.1,Tans Lisa3,Mast Hetty4,van den Bos Renate R.2,Mureau Marc A. M.5,Offerman Marinella P. J.1,Baatenburg de Jong Robert J.1

Affiliation:

1. Department of Otorhinolaryngology and Head and Neck Surgery Erasmus MC Cancer Institute Rotterdam The Netherlands

2. Department of Dermatology Erasmus MC Cancer Institute Rotterdam The Netherlands

3. Department of Radiotherapy Erasmus MC Cancer Institute Rotterdam The Netherlands

4. Department of Oral and Maxillofacial Surgery Erasmus MC Cancer Institute Rotterdam The Netherlands

5. Department of Plastic & Reconstructive Surgery Erasmus MC Cancer Institute Rotterdam The Netherlands

Abstract

AbstractPurposeEarly stage lip squamous cell carcinoma (lip SCC) can be treated with conventional excision, Mohs micrographic surgery (MMS), or brachytherapy. The aim of this retrospective study was to describe the medical outcomes, patient‐reported outcomes, and costs of these treatments.MethodsA retrospective cohort study of T1–T2 lip SSCs treated between 1996 and 2019. Medical outcomes, recurrences, and survival were retrieved from medical records. Facial appearance, facial function, and Quality of Life (QoL) were measured with the Face‐Q H&N and EQ‐5D‐5L questionnaires. Costs were also calculated.ResultsOf the 336 lip SCCs, 122 were treated with excision, 139 with MMS, and 75 with brachytherapy. Locally, the recurrence rate was 2.7% and regionally 4.8%. There were 2% disease‐related deaths. T2‐stage and poor tumor differentiation were associated with recurrences. Posttreatment QoL, facial function, and appearance were rated as good. Brachytherapy was the most expensive treatment modality.ConclusionEarly‐stage lip SCC has a good prognosis, with a disease‐specific survival of 98.2% after a median follow‐up of 36 months, there was a high QoL and satisfaction at long‐term follow‐up. Based on the costs and the risk of locoregional recurrences, we believe that, for most noncomplex lip SCCs, MMS would be the most logical treatment option.

Publisher

Wiley

Subject

General Dentistry,Otorhinolaryngology

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