Neuropsychiatric safety with liraglutide 3.0 mg for weight management: Results from randomized controlled phase 2 and 3a trials

Author:

O'Neil Patrick M.1ORCID,Aroda Vanita R.2,Astrup Arne3,Kushner Robert4,Lau David C. W.5,Wadden Thomas A.6,Brett Jason7,Cancino Ana-Paula8,Wilding John P. H.9,

Affiliation:

1. Weight Management Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina; Charleston South Carolina

2. Department of Internal Medicine, Endocrinology, Diabetes & Metabolism, MedStar Health Research Institute; Georgetown University School of Medicine; Hyattsville Maryland

3. Department of Nutrition, Exercise and Sports; University of Copenhagen; Frederiksberg C Denmark

4. Department of Internal Medicine, Northwestern University Feinberg School of Medicine; Chicago Illinois

5. Departments of Medicine and Biochemistry & Molecular Biology, University of Calgary Cumming School of Medicine; Calgary Alberta Canada

6. Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania; Philadelphia Pennsylvania

7. Novo Nordisk Inc.; Plainsboro New Jersey

8. Novo Nordisk A/S; Søborg Denmark

9. Department of Obesity and Endocrinology, Obesity and Endocrinology Clinical Research Group; University of Liverpool; Liverpool UK

Funder

Novo Nordisk A/S

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference33 articles.

1. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19 · 2 million participants;NCD Risk Factor Collaboration (NCD-RisC);Lancet,2016

2. Ferguson C David S Divine L Obesity drug outcome measures. A consensus report of considerations regarding pharmacologic intervention 2012 http://sphhs.gwu.edu/releases/obesitydrugmeasures.pdf

3. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis;Guh;BMC Public Health,2009

4. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis;Flegal;JAMA,2013

5. Bodyweight, gender, and quality of life: a population-based longitudinal study;Garner;Qual Life Res,2012

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