Use of an integrated modelling and simulation approach to develop a simplified peginterferon alfa-2a dosing regimen for children with hepatitis C

Author:

Brennan Barbara J.1,Lemenuel-Diot Annabelle2,Snoeck Eric3,McKenna Michael4,Solsky Jonathan1,Wat Cynthia4,Mallalieu Navita L.1

Affiliation:

1. Hoffmann-La Roche Inc.; Nutley NJ USA

2. F. Hoffmann-La Roche Ltd; Basel Switzerland

3. SGS Exprimo NV; Mechelen Belgium and

4. Roche Products Ltd; Welwyn UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference19 articles.

1. Hepatitis C 2012 http://www.who.int/mediacentre/factsheets/fs164/en/index.html

2. Neonatal and paediatric posttransfusion hepatitis C: a look back and a look forward;Aach;Pediatrics,2000

3. Managing paediatric hepatitis C: current and emerging treatment options;Karnsakul;Ther Clin Risk Manag,2009

4. Diagnosis, management, and treatment of hepatitis C: an update;Ghany;Hepatology,2009

5. Pharmacokinetics of peginterferons;Zeuzem;Semin Liver Dis,2003

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