Zymogen‐locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice-Reference-Cited by-同舟云学术

Zymogen‐locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice

Published:2021-03-11 Issue:1 Volume:232 Page:
ISSN:1748-1708
Container-title:Acta Physiologica
language:en
Short-container-title:Acta Physiol.

Author:

Essigke Daniel¹,Ilyaskin Alexandr V.²,Wörn Matthias¹,Bohnert Bernhard N.¹³⁴^ORCID,Xiao Mengyun¹,Daniel Christoph⁵,Amann Kerstin⁵,Birkenfeld Andreas L.¹³⁴,Szabo Roman⁶,Bugge Thomas H.⁶,Korbmacher Christoph²,Artunc Ferruh¹³⁴^ORCID

Affiliation:

1. Department of Internal Medicine Division of Endocrinology, Diabetology and Nephrology University Hospital Tübingen Tuebingen Germany

2. Institute of Cellular and Molecular Physiology Friedrich‐Alexander University Erlangen‐Nürnberg (FAU) Erlangen Germany

3. Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen Tuebingen Germany

4. German Center for Diabetes Research (DZD) at the University Tübingen Tuebingen Germany

5. Institute of Pathology Department of Nephropathology Friedrich‐Alexander University Erlangen‐Nürnberg (FAU) Erlangen Germany

6. Proteases and Tissue Remodeling Section National Institute of Dental and Craniofacial ResearchNational Institutes of Health Bethesda MD USA

Funder

Deutsche Forschungsgemeinschaft

National Institute of Dental and Craniofacial Research

Publisher

Wiley

Subject

Physiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/apha.13640

Reference48 articles.

1. Activation of the Epithelial Sodium Channel (ENaC) by Serine Proteases

2. Epithelial Na+ Channel Regulation by Extracellular and Intracellular Factors

3. ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases

4. Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels

5. Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites

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