Association of Accelerometer‐Determined Physical Activity and Sedentary Behavior With the Gut Microbiome in Middle‐Aged Women: A Compositional Data Approach

Author:

Pérez‐Prieto Inmaculada12ORCID,Migueles Jairo H.3,Molina Nerea M.12,Sola‐Leyva Alberto456,Salas‐Espejo Eduardo1,Arffman Riikka K.7,Nurkkala Marjukka89,Niemelä Maisa10ORCID,Lüll Kreete11,Org Elin11,Franks Stephen12,Tapanainen Juha S.1314,Salumets Andres45615,Piltonen Terhi T.7,Ortega Francisco B.31617ORCID,Altmäe Signe1245ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology I, Faculty of Sciences University of Granada Granada Spain

2. Instituto de Investigación Biosanitaria ibs.GRANADA Granada Spain

3. Department of Physical Education and Sports, Faculty of Sport Sciences Sport and Health University Research Institute (iMUDS), University of Granada Granada Spain

4. Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology Karolinska Institutet Huddinge Stockholm Sweden

5. Department of Gynaecology and Reproductive Medicine Karolinska University Hospital Huddinge Stockholm Sweden

6. Competence Centre on Health Technologies Tartu Estonia

7. Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, Medical Research Center Oulu University Hospital, University of Oulu Oulu Finland

8. Department of Sports and Exercise Medicine Oulu Deaconess Institute Foundation sr Oulu Finland

9. Research Unit of Population Health, Faculty of Medicine University of Oulu Oulu Finland

10. Research Unit of Health Sciences and Technology, Medical Faculty University of Oulu Oulu Finland

11. Institute of Genomics, Estonian Genome Centre, University of Tartu Tartu Estonia

12. Faculty of Medicine, Department of Metabolism, Digestion and Reproduction Imperial College London London UK

13. Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital Helsinki Finland

14. Department of Obstetrics and Gynaecology HFR – Cantonal Hospital of Fribourg and University of Fribourg Fribourg Switzerland

15. Department of Obstetrics and Gynaecology Institute of Clinical Medicine, University of Tartu Tartu Estonia

16. CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Granada Spain

17. Faculty of Sport and Health Sciences University of Jyväskylä Jyväskylä Finland

Abstract

ABSTRACTThe beneficial effects of physical activity (PA) on gut microbiome have been reported, nevertheless the findings are inconsistent, with the main limitation of subjective methods for assessing PA. It is well accepted that using an objective assessment of PA reduces the measurement error and also allows objective assessment of sedentary behavior (SB). We aimed to study the associations between accelerometer‐assessed behaviors (i.e., SB, light‐intensity physical activity [LPA] and moderate‐to‐vigorous physical activity [MVPA]) with the gut microbiome using compositional data analysis, a novel approach that enables to study these behaviors accounting for their inter‐dependency. This cross‐sectional study included 289 women from the Northern Finland Birth Cohort 1966. Physical activity was measured during 14 days by wrist‐worn accelerometers. Analyses based on the combined effect of MVPA and SB, and compositional data analyses in association with the gut microbiome data were performed. The microbial alpha‐ and beta‐diversity were not significantly different between the MVPA‐SB groups, and no differentially abundant microorganisms were detected. Compositional data analysis did not show any significant associations between any movement behavior (relative to the others) on microbial alpha‐diversity. Butyrate‐producing bacteria such as Agathobacter and Lachnospiraceae CAG56 were significantly more abundant when reallocating time from LPA or SB to MVPA (γ = 0.609 and 0.113, both p‐values = 0.007). While PA and SB were not associated with microbial diversity, we found associations of these behaviors with specific gut bacteria, suggesting that PA of at least moderate intensity (i.e., MVPA) could increase the abundance of short‐chain fatty acid–producing microbes.

Funder

Oulun Yliopisto

Universidad de Granada

Publisher

Wiley

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