Abacavir pharmacokinetics in African children living with HIV: A pooled analysis describing the effects of age, malnutrition and common concomitant medications

Author:

Tikiso Tjokosela1ORCID,McIlleron Helen12,Burger David3ORCID,Gibb Diana4,Rabie Helena5,Lee Janice6,Lallemant Marc6,Cotton Mark F.5,Archary Moherndran7ORCID,Hennig Stefanie89ORCID,Denti Paolo1ORCID

Affiliation:

1. Division of Clinical Pharmacology, Department of Medicine University of Cape Town Cape Town South Africa

2. Wellcome Centre for Infectious Diseases Research in Africa (CIDRI‐Africa), Institute of Infectious Disease and Molecular Medicine University of Cape Town Cape Town South Africa

3. Department of Pharmacy Radboud University Medical Centre Nijmegen the Netherlands

4. MRC Clinical Trials Unit at University College London London UK

5. Department of Paediatrics and Child Health and Family Centre for Research with Ubuntu (FAM‐CRU) Stellenbosch University and Tygerberg Children's Hospital Cape Town South Africa

6. Drugs for Neglected Diseases initiative Geneva Switzerland

7. Department of Paediatrics and Child Health at King Edward VIII Hospital affiliated to the Nelson R Mandela School of Medicine University of KwaZulu‐Natal South Africa

8. Certara, Inc. Princeton New Jersey USA

9. School of Clinical Sciences, Faculty of Health Queensland University of Technology Brisbane QLD Australia

Funder

Wellcome Trust

Medical Research Council

European and Developing Countries Clinical Trials Partnership

Alexander von Humboldt-Stiftung

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference42 articles.

1. UNAIDS.Global HIV and AIDS statistics – Fact sheet. UNAIDS;2018:6.https://www.unaids.org/en/resources/fact-sheet. Accessed July 21 2021.

2. World Health Organization.Update of recommendations on first‐ and second‐line antiretroviral regimens. World Health Organization;2019:16.https://apps.who.int/iris/bitstream/handle/10665/325892/WHO-CDS-HIV-19.15-eng.pdf. Accessed July 21 2021.

3. Plasma pharmacokinetics of once‐ versus twice‐daily lamivudine and abacavir: simplification of combination treatment in HIV‐1‐infected children (PENTA‐13);Bergshoeff A;Antivir Ther,2005

4. Pharmacokinetic study of once-daily versus twice-daily abacavir and lamivudine in HIV type-1-infected children aged 3-<36 months

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