Effect of enzalutamide on PK of P‐gp and BCRP substrates in cancer patients: CYP450 induction may not always predict overall effect on transporters
Author:
Affiliation:
1. Astellas Pharma Inc. Northbrook Illinois USA
2. PMSI Republican Clinical Hospital “Timofei, Moşneaga,” ARENSIA EM Chişinău Moldova
3. Pfizer Inc. San Diego California USA
Funder
Pfizer
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13229
Reference33 articles.
1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2. Polypharmacy in elderly patients with cancer: clinical implications and management
3. The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010
4. Drug–Drug Interaction Potential of Darolutamide: In Vitro and Clinical Studies
5. Evaluation of Clinically Relevant Drug–Drug Interactions and Population Pharmacokinetics of Darolutamide in Patients with Nonmetastatic Castration-Resistant Prostate Cancer: Results of Pre-Specified and Post Hoc Analyses of the Phase III ARAMIS Trial
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