Higher IGFBP3 is associated with increased incidence of colorectal cancer in older men independently of IGF1

Author:

Chan Yi X.12ORCID,Alfonso Helman3,Paul Chubb Stephen Anthony14,Ho Ken K. Y.5ORCID,Gerard Fegan Peter2,Hankey Graeme J.16,Golledge Jonathan78,Flicker Leon19,Yeap Bu B.12ORCID

Affiliation:

1. School of Medicine; University of Western Australia; Perth WA Australia

2. Department of Endocrinology and Diabetes; Fiona Stanley Hospital; Perth WA Australia

3. School of Public Health; Department of Epidemiology and Biostatistics; Curtin University; Perth WA Australia

4. Pathwest Laboratory Medicine; Fiona Stanley Hospital; Perth WA Australia

5. Department of Diabetes and Endocrinology; Princess Alexandra Hospital; Brisbane QLD Australia

6. Department of Neurology; Sir Charles Gairdner Hospital; Perth WA Australia

7. Queensland Research Centre for Peripheral Vascular Disease; College of Medicine and Dentistry; James Cook University; Townsville QLD Australia

8. Department of Vascular and Endovascular Surgery; The Townsville Hospital; Townsville QLD Australia

9. Western Australian Centre for Health and Ageing; Centre for Medical Research; University of Western Australia; Perth WA Australia

Funder

National Health and Medical Research Council

The Health In Men Study

University of Western Australia

Queensland Government

Publisher

Wiley

Subject

Endocrinology, Diabetes and Metabolism,Endocrinology

Reference31 articles.

1. IARC World Cancer Report 2014 International Agency for Research on Cancer, World Health Organisation Lyon 2014

2. Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies;Roddam;Ann Intern Med,2008

3. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis;Renehan;Lancet,2004

4. Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies;Rinaldi;Int J Cancer,2010

5. Circulation insulin-like growth factor peptides and colorectal cancer risk: an updated systematic review and meta-analysis;Chi;Mol Biol Rep,2013

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