Affiliation:
1. Graduate Program in Biochemistry The Graduate Center of The City University of New York New York New York USA
2. Neuroscience Initiative, Advanced Science Research Center The Graduate Center of The City University of New York New York New York USA
3. Graduate Program in Biology The Graduate Center of The City University of New York New York New York USA
Abstract
AbstractThe epigenetic landscape of oligodendrocyte lineage cells refers to the cell‐specific modifications of DNA, chromatin, and RNA that define a unique gene expression pattern of functionally specialized cells. Here, we focus on the epigenetic changes occurring as progenitors differentiate into myelin‐forming cells and respond to the local environment. First, modifications of DNA, RNA, nucleosomal histones, key principles of chromatin organization, topologically associating domains, and local remodeling will be reviewed. Then, the relationship between epigenetic modulators and RNA processing will be explored. Finally, the reciprocal relationship between the epigenome as a determinant of the mechanical properties of cell nuclei and the target of mechanotransduction will be discussed. The overall goal is to provide an interpretative key on how epigenetic changes may account for the heterogeneity of the transcriptional profiles identified in this lineage.
Funder
National Institute of Neurological Disorders and Stroke
Subject
History and Philosophy of Science,General Biochemistry, Genetics and Molecular Biology,General Neuroscience
Cited by
8 articles.
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