The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome

Author:

Mohr Sandra1,Fritz Nikola1,Hammer Christian23ORCID,Martínez Cristina145ORCID,Berens Sabrina6ORCID,Schmitteckert Stefanie1ORCID,Wahl Verena1,Schmidt Malin17,Houghton Lesley A.89ORCID,Goebel‐Stengel Miriam1011,Kabisch Maria12,Götze Dorothea1,Milovač Irina13,D’Amato Mauro14151617ORCID,Zheng Tenghao1415ORCID,Röth Ralph118,Mönnikes Hubert19,Engel Felicitas6ORCID,Gauss Annika20ORCID,Tesarz Jonas6ORCID,Raithel Martin21ORCID,Andresen Viola22ORCID,Frieling Thomas23ORCID,Keller Jutta22ORCID,Pehl Christian24,Stein‐Thöringer Christoph25ORCID,Clarke Gerard2627ORCID,Kennedy Paul J.2627ORCID,Cryan John F.262728ORCID,Dinan Timothy G.2627ORCID,Quigley Eamonn M. M.2729ORCID,Spiller Robin30ORCID,Beltrán Caroll31,Madrid Ana María31ORCID,Torres Verónica31,Pérez de Arce Edith31ORCID,Herzog Wolfgang6ORCID,Mayer Emeran A.32ORCID,Sayuk Gregory33ORCID,Gazouli Maria34ORCID,Karamanolis George35ORCID,Kapur‐Pojskič Lejla36ORCID,Bustamante Mariona3738ORCID,Rabionet Raquel39ORCID,Estivil Xavier37ORCID,Franke André40ORCID,Lieb Wolfgang41ORCID,Boeckxstaens Guy42ORCID,Wouters Mira M.42ORCID,Simrén Magnus43ORCID,Rappold Gudrun A.144ORCID,Vicario Maria45ORCID,Santos Javier45ORCID,Schaefert Rainer4647ORCID,Lorenzo‐Bermejo Justo12ORCID,Niesler Beate11844ORCID

Affiliation:

1. Department of Human Molecular Genetics Institute of Human Genetics Heidelberg University Hospital Heidelberg Germany

2. Department of Cancer Immunology Genentech South San Francisco CA USA

3. Department of Human Genetics Genentech South San Francisco CA USA

4. Institut de Recerca Biomèdica de Lleida (IRBLleida) Lleida Spain

5. Lleida Institute for Biomedical Research Dr. Pifarré Foundation (IRBLleida) Lleida Spain

6. Department of General Internal Medicine and Psychosomatics Heidelberg University Hospital Heidelberg Germany

7. Department of Translational Brain Research Central Institute of Mental Health

8. St. James’s University Hospital University of Leeds Leeds UK

9. Mayo Clinic Jacksonville FL USA

10. Department of Psychosomatic Medicine University Hospital Tübingen Tübingen Germany

11. Department of Internal Medicine and Gastroenterology HELIOS Clinic Rottweil Rottweil Germany

12. Institute of Medical Biometry and Informatics Heidelberg University Heidelberg Germany

13. Faculty of Medicine University Banja Luka Banja Luka Bosnia and Herzegovina

14. School of Biological Sciences Monash University Clayton VIC Australia

15. Unit of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Stockholm Sweden

16. Department of Gastrointestinal and Liver Diseases Biodonostia HRI San Sebastián Spain

17. IKERBASQUE Basque Foundation for Science Bilbao Spain

18. nCounter Core Facility Department of Human Molecular Genetics Heidelberg University Hospital Heidelberg Germany

19. Martin‐Luther‐Hospital Berlin Germany

20. Department of Gastroenterology, Infectious Diseases and Intoxications Heidelberg University Heidelberg Germany

21. University of Erlangen Erlangen Germany

22. Israelitisches Krankenhaus Hamburg Germany

23. Helios Klinik Krefeld Krefeld Germany

24. Krankenhaus Vilsbiburg Vilsbiburg Germany

25. German Cancer Research Center Heidelberg Germany

26. Department of Psychiatry and Neurobehavioral Science University College Cork Cork Ireland

27. APC Microbiome Ireland University College Cork Cork Ireland

28. Department of Anatomy and Neuroscience University College Cork Cork Ireland

29. Lynda K. and David M. Underwood Center for Digestive Disorders Houston Methodist Hospital Weill Cornell Medical College Houston TX USA

30. Nottingham Digestive Diseases Centre University of Nottingham Nottingham UK

31. Gastroenterology Unit Hospital Clínico Universidad de Chile Medicine Department Universidad de Chile Santiago de Chile Chile

32. Oppenheimer Center for Neurobiology of Stress University of California Los Angeles CA USA

33. Washington University School of Medicine St. Louis MO USA

34. Laboratory of Biology Medical School National and Kapodistrian University of Athens Athens Greece

35. Academic Department of Gastroenterology Medical School National and Kapodistrian University of Athens "Laikon" General Hospital Athens Greece

36. Institute for Genetic Engineering and Biotechnology University of Sarajevo Sarajevo Bosnia and Herzegovina

37. CRG Centre for Genomic Regulation Barcelona Spain

38. ISGlobal Barcelona Spain

39. Department of Genetics, Microbiology and Statistics Faculty of Biology IBUB CIBERER IRSJD Universitat de Barcelona Barcelona Spain

40. Institute of Clinical Molecular Biology Kiel Germany

41. Institute of Epidemiology Kiel Germany

42. TARGID University Hospital Leuven Leuven Belgium

43. Institute of Medicine University of Gothenburg Gothenburg Sweden

44. Interdisciplinary Center for Neurosciences (IZN) Heidelberg University Heidelberg Germany

45. Institut de Recerca Vall d’Hebron Hospital Vall d'Hebron Barcelona Spain

46. Department of Psychosomatic Medicine Division of Internal Medicine University Hospital Basel Basel Switzerland

47. Faculty of Medicine University of Basel Basel Switzerland

Funder

Marianne and Marcus Wallenberg Foundation

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference53 articles.

1. Bowel disorders;Mearin F;Gastroenterology,2016

2. Irritable bowel syndrome;Enck P;Nat Rev Dis Prim,2016

3. IBS and IBD — separate entities or on a spectrum?

4. Worldwide prevalence and burden of functional gastrointestinal disorders, results of rome foundation global study;Sperber AD;Gastroenterology,2020

5. Global burden of irritable bowel syndrome: trends, predictions and risk factors

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