Libertas: rationale and study design of a multicentre, Phase II, double-blind, randomised, placebo-controlled investigation to evaluate the efficacy, safety and tolerability of locally applied NRL001 in patients with faecal incontinence
Author:
Affiliation:
1. Gastroenterology Unit; CHU Pontchaillou; Rennes France
2. Norgine Limited; Uxbridge UK
3. Division of Surgery; Queen's Medical Centre; University Hospital Nottingham; Nottingham UK
Publisher
Wiley
Subject
Gastroenterology
Reference34 articles.
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3. Epidemiology of fecal incontinence: the silent affliction;Johanson;Am J Gastroenterol,1996
4. Fecal incontinence: prevalence, severity, and quality of life data from an outpatient gastroenterology practice;Alsheik;Gastroenterol Res Pract,2012
5. National Institute for Health and Clinical Excellence Faecal Incontinence: The Management of Faecal Incontinence in Adults www.nice.org.uk/CG049
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4. Libertas: a phase II placebo-controlled study of NRL001 in patients with faecal incontinence showed an unexpected and sustained placebo response;International Journal of Colorectal Disease;2016-04-13
5. Faecal incontinence: Current knowledges and perspectives;World Journal of Gastrointestinal Pathophysiology;2016
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