Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation

Author:

McEwan Ashley123ORCID,Greenwood Matthew145ORCID,Ward Christopher145,Ritchie David678,Szer Jeff678ORCID,Gardiner Elizabeth9,Colic Andriana1,Sipavicius Julija1,Panek‐Hudson Yvonne67,Kerridge Ian145

Affiliation:

1. Haematology Department Royal North Shore Hospital Sydney New South Wales Australia

2. Haematology Department Liverpool Hospital Sydney New South Wales Australia

3. South West Sydney Clinical School Faculty of Medicine, University of New South Wales Sydney New South Wales Australia

4. Northern Clinical School, Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia

5. Northern Blood Research Centre, Kolling Institute University of Sydney Sydney New South Wales Australia

6. Peter MacCallum Cancer Centre Peter MacCallum Cancer Centre Melbourne Victoria Australia

7. Haematology Department Royal Melbourne Hospital Melbourne Victoria Australia

8. University of Melbourne University of Melbourne Melbourne Victoria Australia

9. John Curtin School of Medical Research at the Australian National University Canberra Australian Capital Territory Australia

Abstract

AbstractHaematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient‐ and transplant‐specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant‐associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.

Publisher

Wiley

Subject

Internal Medicine

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