First complete remission favours haploidentical haematopoietic stem cell transplantation with post‐transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia-Reference-Cited by-同舟云学术

First complete remission favours haploidentical haematopoietic stem cell transplantation with post‐transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia

Published:2024-02-29 Issue:5 Volume:204 Page:1913-1919
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Jo Tomoyasu¹²^ORCID,Ueda Tomoaki³,Akahoshi Yu⁴^ORCID,Kondo Tadakazu¹⁵^ORCID,Uchida Naoyuki⁶^ORCID,Tanaka Masatsugu⁷,Nakamae Hirohisa⁸^ORCID,Doki Noriko⁹,Ota Shuichi¹⁰^ORCID,Sawa Masashi¹¹,Ohigashi Hiroyuki¹²,Maruyama Yumiko¹³,Takayama Nobuyuki¹⁴,Nishida Tetsuya¹⁵,Hiramoto Nobuhiro⁵,Katayama Yuta¹⁶,Kanda Yoshinobu¹⁷^ORCID,Ichinohe Tatsuo¹⁸,Atsuta Yoshiko¹⁹²⁰^ORCID,Arai Yasuyuki¹²^ORCID,

Affiliation:

1. Department of Hematology and Oncology, Graduate School of Medicine Kyoto University Kyoto Japan

2. Center for Research and Application of Cellular Therapy Kyoto University Hospital Kyoto Japan

3. Department of Hematology and Oncology Osaka University Graduate School of Medicine Suita Japan

4. Division of Hematology Jichi Medical University Saitama Medical Center Saitama Japan

5. Department of Hematology Kobe City Medical Center General Hospital Kobe Japan

6. Department of Hematology Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital Tokyo Japan

7. Department of Hematology, Kanagawa Cancer Center Kanagawa Japan

8. Department of Hematology Osaka Metropolitan University Hospital Osaka Japan

9. Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital Tokyo Japan

10. Department of Hematology Sapporo Hokuyu Hospital Sapporo Japan

11. Department of Hematology and Oncology Anjo Kosei Hospital Anjo Japan

12. Department of Hematology Hokkaido University Hospital Sapporo Japan

13. Department of Hematology University of Tsukuba Hospital Tsukuba Japan

14. Department of Hematology Kyorin University Hospital Mitaka Japan

15. Department of Hematology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya Japan

16. Department of Hematology Hiroshima Red Cross Hospital and Atomic‐bomb Survivors Hospital Hiroshima Japan

17. Division of Hematology Jichi Medical University Tochigi Japan

18. Department of Hematology and Oncology Research Institute for Radiation Biology and Medicine, Hiroshima University Hiroshima Japan

19. Japanese Data Center for Hematopoietic Cell Transplantation Nagoya Japan

20. Department of Registry Science for Transplant and Cellular Therapy Aichi Medical University School of Medicine Nagakute Japan

Abstract

SummaryTo assess the benefits of HLA‐haploidentical haematopoietic stem cell transplantation using post‐transplant cyclophosphamide (PTCy‐haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy‐haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy‐haplo was associated with a significantly higher relapse rate, but lower non‐relapse mortality, which results in overall survival and disease‐free survival, comparable to those of UCB. Among patients in CR1, PTCy‐haplo showed a significantly higher survival than UCB regardless of the CD34+ cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19372

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