The Impact of Active Site Mutations of South African HIV PR on Drug Resistance: Insight from Molecular Dynamics Simulations, Binding Free Energy and Per-Residue Footprints-Reference-Cited by-同舟云学术

The Impact of Active Site Mutations of South African HIV PR on Drug Resistance: Insight from Molecular Dynamics Simulations, Binding Free Energy and Per-Residue Footprints

Published:2014-03-18 Issue:4 Volume:83 Page:472-481
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Ahmed Shaimaa M.¹,Maguire Glenn E. M.²,Kruger Hendrik G.²,Govender Thirumala¹

Affiliation:

1. Discipline of Pharmaceutical Sciences; School of Health Sciences; University of KwaZulu-Natal; Durban 4001 South Africa

2. Center of Catalysis and Peptide Synthesis; School of Health Sciences; University of KwaZulu-Natal; Durban 4001 South Africa

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12262/fullpdf

Reference40 articles.

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3. Three-dimensional structure of Aspartyl protease from human immunodeficiency virus HIV-1;Navia;Nature,1989

4. Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes;Prabu-Jeyabalan;Structure,2002

5. X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor;Swain;Proc Natl Acad Sci USA,1990

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