TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds’ pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development-Reference-Cited by-同舟云学术

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TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds’ pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development

Published:2018-02-16 Issue:3 Volume:223 Page:e13038
ISSN:1748-1708
Container-title:Acta Physiologica
language:en
Short-container-title:Acta Physiol

Author:

Garami A.¹²,Pakai E.¹²,McDonald H. A.³,Reilly R. M.³,Gomtsyan A.³,Corrigan J. J.¹,Pinter E.⁴,Zhu D. X. D.⁵,Lehto S. G.⁵,Gavva N. R.⁵,Kym P. R.³,Romanovsky A. A.¹

Affiliation:

1. Systemic Inflammation Laboratory (FeverLab); Trauma Research; St. Joseph's Hospital and Medical Center; Phoenix AZ USA

2. Institute for Translational Medicine; Medical School; University of Pecs; Pecs Hungary

3. Neuroscience Research; Global Pharmaceutical Research and Development; AbbVie; North Chicago IL USA

4. Department of Pharmacology and Pharmacotherapy; Medical School and Janos Szentagothai Research Centre; University of Pecs; Pecs Hungary

5. Department of Neuroscience; Amgen; Thousand Oaks CA USA

Funder

National Research, Development and Innovation Office

New National Excellence Program of the Hungarian Ministry of Human Capacities

Publisher

Wiley

Subject

Physiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/apha.13038/fullpdf

Reference86 articles.

1. Analgesic potential of TRPV1 antagonists;Kym;Biochem Pharmacol,2009

2. Targeting TRP channels for pain relief;Brederson;Eur J Pharmacol,2013

3. Modulation of the TRPV1 channel: current clinical trials and recent patents with focus on neurological conditions;De Petrocellis;Recent Pat CNS Drug Discov,2013

4. Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist;Swanson;J Med Chem,2005

5. The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation;Gavva;J Neurosci,2007

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