A single dose of intravenous combretastatin A4-phosphate is reasonably well tolerated and significantly reduces tumour vascularization in canine spontaneous cancers

Author:

Abma E.12ORCID,De Spiegelaere W.3,Vanderperren K.4,Stock E.4,Van Brantegem L.5,Cornelis I.1ORCID,Daminet S.1,Ni Y.6,Vynck M.7,Verstraete G.8,Smets P.1,de Rooster H.12

Affiliation:

1. Small Animal Department, Faculty of Veterinary Medicine; Ghent University; Ghent Belgium

2. Cancer Research Institute Ghent (CRIG), Medical Research Building; University Hospital Ghent; Ghent Belgium

3. Department of Morphology, Faculty of Veterinary Medicine; Ghent University; Ghent Belgium

4. Department of Medical Imaging and Orthopedics of Small Animals, Faculty of Veterinary Medicine; University of Ghent; Ghent Belgium

5. Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine; Ghent University; Ghent Belgium

6. Theragnostic Lab, Department of Imaging and Pathology; KU Leuven; Leuven Belgium

7. Department of Data Analysis and Mathematical Modeling, Faculty of Bioscience Engineering; Ghent University; Ghent Belgium

8. Laboratory of Pharmaceutical Technology; Ghent University; Ghent Belgium

Funder

Agency for Innovation & Entrepreneurship

Belgian Animal Cancer Foundation

Publisher

Wiley

Subject

General Veterinary

Reference54 articles.

1. The tumour microcirculation as a target in cancer therapy: a clearer perspective;Denekamp;Eur J Clin Invest,1999

2. Vascular targeting agents as cancer therapeutics;Thorpe;Clin Cancer Res,2004

3. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents;Siemann;Cancer Treat Rev,2011

4. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature;Dark;Cancer Res,1997

5. Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate;Chaplin;Anticancer Res,1999

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