Affiliation:
1. Pathophysiology of Mental Disorders Nagoya University Graduate School of Medicine Nagoya Japan
2. Center for Advanced Medicine and Clinical Research Nagoya University Hospital Nagoya Japan
3. Hospital Pharmacy Nagoya University Hospital Nagoya Japan
4. BDR‐Otsuka Pharmaceutical Collaboration Center, RIKEN Center for Biosystems Dynamics Research Kobe Japan
5. Institute for Glyco‐core Research (iGCORE) Nagoya University Nagoya Japan
Abstract
Mental disorders are considered as one of the major healthcare issues worldwide owing to their significant impact on the quality of life of patients, causing serious social burdens. However, it is hard to examine the living brain—a source of psychiatric symptoms—at the cellular, subcellular, and molecular levels, which poses difficulty in determining the pathogenesis and pathophysiology of mental disorders. Recently, induced pluripotent stem cell (iPSC) technology has been used as a novel tool for research on mental disorders. We believe that the iPSC‐based studies will address the limitations of other research approaches, such as human genome, postmortem brain study, brain imaging, and animal model analysis. Notably, studies using integrated iPSC technology with genetic information have provided significant novel findings to date. This review aimed to discuss the history, current trends, potential, and future of iPSC technology in the field of mental disorders. Although iPSC technology has several limitations, this technology can be used in combination with the other approaches to facilitate studies on mental disorders.
Funder
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Subject
Psychiatry and Mental health,Neurology (clinical),Neurology,General Medicine,General Neuroscience
Cited by
2 articles.
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