High-Level Fluoroquinolone Resistance inPseudomonas aeruginosaDue to Interplay of the MexAB-OprM Efflux Pump and the DNA Gyrase Mutation
Author:
Affiliation:
1. Department of Molecular Life Science; Tokai University School of Medicine; Isehara Kanagawa 259-1193 Japan
Publisher
Wiley
Subject
Virology,Immunology,Microbiology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1348-0421.2002.tb02711.x/fullpdf
Reference11 articles.
1. Involvement of an efflux system in mediating high level of fluoroquinolone resistance in Mycobacterium smegmatis;Banerjee;Biochem. Biophys. Res. Commun.,1996
2. Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance;Bast;Antimicrob. Agents Chemother.,2000
3. Some properties of subunits of DNA gyrase from Pseudomonas aeruginosa PAO1 and its nalidixic acid-resistant mutnat;Inoue;J. Bacteriol.,1987
4. Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa;Kitamura;Antimicrob. Agents Chemother.,1995
5. Assignment of the substrate-selective subunits of the MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa;Maseda;Antimicrob. Agents Chemother.,2000
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