Wild‐type and mutant SOD1 localizes to RNA‐rich structures in cells and mice but does not bind RNA
Author:
Affiliation:
1. Department of Cellular and Molecular Medicine Faculty of Medicine University of Ottawa Ottawa Canada
2. The Eric Poulin Centre for Neuromuscular Disease Ottawa ON Canada
3. Department of Chemistry University of Waterloo Waterloo ON Canada
Funder
Natural Sciences and Engineering Research Council of Canada
Institute of Genetics
ALS Society of Canada
Health Research
Science and Engineering Research Council
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15126
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2. RNA-Seq Profiling of Spinal Cord Motor Neurons from a Presymptomatic SOD1 ALS Mouse
3. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.
4. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
5. Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis
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