Functional evidence for altered activity of gabaergic receptors following chronic desipramine treatment in rats

Abstract

Abstract The antinociceptive effect of subcutaneous 4,5,6,7-tetrahydroisoxazol[5,4-c]pyridin-3-ol (THIP) or (±)-baclofen, measured as reaction time of rats placed on a plate heated to 55 °C, was assessed after a single or the last repeated (18 consecutive days) dose (5 mg kg−1 once daily) of subcutaneous desipramine. Baclofen (10 mg kg−1)-induced antinociception was reduced by acute and unaffected by chronic desipramine treatment. On the contrary, THIP (20 mg kg−1)-induced antinociception was unaffected by acute and reduced by chronic desipramine.