The Power-consumption-controlled Extruder: A Tool for Pellet Production

Author:

Kleinebudde P1,Sølvberg A J1,Lindner H1

Affiliation:

1. Department of Pharmaceutics and Biopharmaceutics, Christian- Albrechts-University, Gutenbergstraße 76/78, 24118 Kiel, Germany

Abstract

Abstract Based on the assumption that there is a link between power consumption of an extruder and pellet properties, a control circuit for power consumption was developed. Powder and granulation liquid are feeded separately into a twin-screw extruder. The power consumption is controlled by varying the pump rate at a given powder-feed rate; consequently each level of power consumption results in a specific water content of the extrudate for a particular formulation. The shape of pellets depends almost entirely on the level of power consumption irrespective of formulation. The size of dry pellets is additionally affected by a shrinking factor which depends on the water content. The power-consumption-controlled extruder is an appropriate tool for the production of pellets. The system is able to adapt the water content for a formulation automatically.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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