Affiliation:
1. School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852, Japan
Abstract
Abstract
Absorption of organic anions (phenol red, bromphenol blue and bromosulphonphthalein) has been studied after their application to rat liver surface in-vivo, employing a cylindrical glass cell (i.d. 9 mm, area 0·64 cm2). Each drug appeared gradually in the blood with the peak level at about 1 h, after which its concentration declined slowly. Absorbed model drug was efficiently excreted into the bile. These observations appear to indicate the possibility of drug absorption from liver surface membrane. Absorption of model drugs was estimated to be more than 59% in 6 h. The biliary recovery and metabolism of phenol red did not change as compared with that after intravenous administration.
Funder
Ministry of Education, Science and Culture, Japan.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference9 articles.
1. Evidence for the existence of a carrier for bromosulphonphthalein in the liver cell plasma membrane;Frezza;FEBS Lett.,1974
2. The chemical forms in which phenol red is secreted into bile of rats;Hart;Proc. Soc. Exp. Biol. Med.,1966
3. Effect of chronic administration of phenobarbital on the hepatobiliary transport of phenol red: assessment by statistical moment analysis;Kakutani;Pharm. Res.,1992
4. Mechanisms of bile formation, hepatic uptake, and biliary excretion;Klaassen;Pharmacol. Rev.,1984
5. Renal organic anion transport system: pharmacological, physiological, and biochemical aspects;Moller;Pharmacol. Rev.,1983
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