A critical assessment of an accelerated storage test

Abstract

Abstract The accelerated storage test proposed by Rogers enables the rate constant (at a known temperature) and the energy of activation of a reaction occurring in solution to be calculated from a single experiment. This test has been applied to a number of first and second order reactions, including the heat inactivation of horse serum cholin-esterase. The theoretical and practical limitations of the technique are discussed. It is concluded that the test has an important role in determining the stability of pharmaceutical and related compounds in solution and in comparing the stabilities of different batches of the same preparation.