A method for the evaluation of some oral prolonged-release forms of dexamphetamine in man, using urinary excretion data

Author:

BECKETT A H1,TUCKER G T1

Affiliation:

1. Department of Pharmacy, Chelsea College of Science and Technology (University of London), Manresa Road, S.W.3

Abstract

Abstract ALTHOUGH urinary excretion studies (Campbell, Nelson & Chapman, 1959; Chapman, Shenoy & Campbell, 1959; Shenoy, Chapman & Campbell, 1959) have been used as a technique to evaluate prolonged-release dosage forms of amphetamine, the significance of the results is in doubt because of the use of non-specific assay methods and the failure to control urinary pH. The use of radioactive material has indicated the similarity between a dose of 5 mg amphetamine three times a day and a 15 mg prolonged release preparation (Rosen, Tannenbaum, Ellison, Free & Crosley, 1965).

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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