Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs-Reference-Cited by-同舟云学术

Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs

Published:1984-07 Issue:7 Volume:36 Page:431-436
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Ratcliffe J H¹,Hunneyball I M²,Smith A²,Wilson C G¹,Davis S S¹

Affiliation:

1. Departments of Pharmacy, Pharmacology and Physiology, University of Nottingham, NG7 2UH, UK

2. The Research Department, The Boots Company PLC, Nottingham, NG2 3AA, UK

Abstract

Abstract Colloidal suspensions of four biodegradable polymers, polylactic acid (PLA), polybutylcyanoacrylate (PBCA), gelatin (PG) and albumin (PA) were prepared within the size range 1–10 μm. In-vivo biocompatibility tests with synovial tissues were carried out to assess the irritancy of the polymers following intra-articular injection into rabbit knee joints. PLA, PBCA and PG were found to cause joint inflammation whereas PA was well tolerated by the tissues. PA microspheres may provide a means of sustaining the release and reducing the rate of clearance of drugs from the knee joint.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/36/7/431/37468762/j.2042-7158.1984.tb04419.x.pdf

Reference33 articles.

1. A New Long-Acting Injectable Microcapsule System for the Administration of Progesterone*

2. A thermographic and clinical comparison of three intra-articular steroid preparations in rheumatoid arthritis.

3. Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties

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