Affiliation:
1. Departamento de Fisiologia, Facultad de Medicina, Universidad Aulónoma, 28029 Madrid, Spain
Abstract
Abstract
The effects of endothelin-1 (10−10-10−7 M) were isometrically recorded in 4 mm cylindrical segments from the middle cerebral artery of dogs. Cumulative application of endothelin-1 produced marked, sustained contraction of arteries in a concentration-dependent-manner, the maximal response being about 2.6 times higher than that achieved with KCl (50 mM). The contraction by endothelin-1 was unaffected either by endothelium removal or by the cyclo-oxygenase inhibitors indomethacin (10−6 M) and meclofenamate (10−6 M). In a Ca2+ -low (25 μM) solution the endothelin-1-induced arterial contraction was decreased. Therefore, the cerebral vasoconstriction induced by endothelin-1 could be caused by activation of specific receptors located on smooth muscle cells which would lead to the influx of extracellular calcium and vascular musculature contraction.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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