Effects of Calcium Antagonists on the Erythrocyte Membrane-Reference-Cited by-同舟云学术

Effects of Calcium Antagonists on the Erythrocyte Membrane

Published:1991-01 Issue:1 Volume:43 Page:22-26
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Abe Hiroko¹,Katada Keiko¹,Orita Machiko¹,Nishikibe Masaru²

Affiliation:

1. First Department, The Research Institute of Oriental Medicine, Kinki University, Ohno-higashi Osakasayama-shi, Osaka 589, Japan

2. Central Research Laboratories, Banyu Pharmaceutical Co. Ltd, Shimomeguro, Meguro-ku, Tokyo 153, Japan

Abstract

Abstract The effects of dihydropyridine compounds nimodipine, nicardipine and NB818 (isopropyl methyl-6-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-2-methyl-3,5-pyridine-dicarboxylate) on erythrocyte membranes have been studied. These compounds showed protective effects against hypotonic haemolysis, but not against heat-induced haemolysis. An increase in deformability of erythrocytes by these calcium antagonists was observed using a capillary tube centrifugal method. The erythrocytes showed slight stomatocytosis after 30 min of incubation with calcium antagonists, but did not show significant changes in mean corpuscular volume and ATP levels.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/43/1/22/37240544/j.2042-7158.1991.tb05441.x.pdf

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