Affiliation:
1. Department of Pharmacology and Therapeutics, University of Dundee, Dundee DD1 4HN, UK
Abstract
Abstract
S-(-)-Warfarin was found to be a more potent anticoagulant than R-(+)-warfarin in man. However, S-warfarin was cleared more rapidly from the plasma; respective mean plasma half-lives (from four subjects) for R and S-warfarin were 45ṁ4 and 33ṁ0h. Unlike the assay of Lewis, Ilnicki & Carlstrom (1970), the assay of Corn & Berberich (1967) for measuring plasma warfarin gave spuriously long half-life values, particularly with R-warfarin. The apparent volumes of distribution of the enantiomers were not significantly different. A major plasma metabolite detected was warfarin alcohol1, which was seen in much greater quantities after giving R-warfarin than after S-warfarin. The corresponding diastereoisomer, warfarin alcohol2, was seen in trace amounts after S-warfarin only.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
111 articles.
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