Affiliation:
1. Department of Pharmacy, University of Manchester, Manchester, M13 9PL, U.K.
Abstract
Abstract
A series of aminoalkylaminoanthraquinones have been prepared as potential intercalating agents. The binding to DNA of these compounds and the known intercalating drugs chloroquine, lucanthone, daunorubicin and doxorubicin has been characterized by spectrophotometric titration. The association constant for the interaction with DNA has been determined for each compound from a Scatchard plot. The compounds synthesized had association constants between 0.5 and 4.2 × 106 compared with 0.93, 0.90, 3.10 and 2.49 × 106 for chloroquine, lucanthone, daunorubicin and doxorubicin respectively.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
57 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献