Inhibitory Effect of NZ-105, a 1,4-Dihydropyridine Derivative, on Cyclic Nucloeotide Phosphodiesterase Activity-Reference-Cited by-同舟云学术

Inhibitory Effect of NZ-105, a 1,4-Dihydropyridine Derivative, on Cyclic Nucloeotide Phosphodiesterase Activity

Published:1993-06 Issue:6 Volume:45 Page:530-534
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Yamashita Toru¹,Masuda Yukinori¹,Sakai Toshinori¹,Tanaka Sakuya¹,Kasuya Yutaka²

Affiliation:

1. Shiraoka Research Station of Biological Science, Nissan Chemical Industries Ltd., Saitama 349–02, Japan

2. Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo 142, Japan

Abstract

Abstract The effects of NZ-105, a 1,4-dihydropyridine calcium antagonist, on the intracellular cyclic nucleotide system were investigated in-vitro. In rabbit isolated aorta, both NZ-105 (1 and 10 μm) and nicardipine significantly and in a concentration-dependent manner increased intracellular cyclic AMP and cyclic GMP content. NZ-105 inhibited bovine cardiac phosphodiesterase activity (Ki 30 μm) by competitive antagonism. The concentration ranges for inhibition were consistent with the range of increases in cyclic nucleotides.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/45/6/530/37244871/j.2042-7158.1993.tb05593.x.pdf

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