Affiliation:
1. Center of Internal Medicine (Medizinische Klinik II), Justus-Liebig-University, D-35385 Giessen, Germany
Abstract
Abstract
Chronic daily application of (±)-isoprenaline induced a selective-down regulation of β-adrenoceptors in the kidney: the concentration of [3H]dihydroalprenolol binding sites was significantly lowered by isoprenaline treatment while [3H]prazosin and [3H]rauwolscine binding, representing α1-and α2-adrenoceptors, respectively, was not markedly altered. Since the proportion of high- and low-affinity sites for the non-selective α- but relatively β1-selective agonist (–)-noradrenaline remained constant and since in [3H]dihydroalprenolol competition experiments the high- and low-affinity site ratio fitted well to the β1/β2 relation, determined independently by employing ICI 118551 as a β2-selective ligand, a parallel decrease of both β1- and β2-adrenoceptor density can be concluded.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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