A Note on the Oxidative Deamination of Isomers of 5-Hydroxytryptamine and Other Indolealkylamines-Reference-Cited by-同舟云学术

A Note on the Oxidative Deamination of Isomers of 5-Hydroxytryptamine and Other Indolealkylamines

Published:1960-09 Issue:1 Volume:12 Page:761-764
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Erspamer V¹²,Ferrini R¹²,Glässer A¹²

Affiliation:

1. Farmitalia Research Laboratories, Milan

2. The Institute of Pharmacology, University of Parma, Parma, Italy

Abstract

Abstract Monoamine oxidase from guinea pig tissues oxidises 4-hydroxy-tryptamine, 6-hydroxytryptamine and 7-hydroxytryptamine at about 50–70 per cent of the rate of 5-hydroxytryptamine. For the rat liver the relative rate of oxidation of 6-hydroxytryptamine is less. 5-Methoxytryptamine and tryptamine are substrates for amine oxidase as good as, or better than 5-hydroxytryptamine, whereas iso-5-hydroxytryptamine and iso-tryptamine are oxidised less readily than 5-hydroxytryptamine and tryptamine. 5-Hydroxy-β-hydroxy-NN-dimethyltryptamine(β-hydroxybufotenine) does not seem to be a substrate for amine oxidase from guinea pig kidney.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/12/1/761/37754090/j.2042-7158.1960.tb12743.x.pdf

Reference5 articles.

1. ISOLATION OF 5-METHOXYINDOLE-3-ACETIC ACID FROM BOVINE PINEAL GLANDS1

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Disposition of a Series of Tetrahydrocarbazoles;Drug Metabolism Reviews;1980-01

2. The crystal and molecular structures of 1:1 molecular complexes between tryptophan metabolites – 5-methoxyindole-3-acetic acid:5-methoxytryptamine and indole-3-acetic acid:5-methoxytryptamine;Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry;1976-12-01

3. Metabolism of indolealkylamines;5-Hydroxytryptamine and Related Indolealkylamines;1966

4. Inhibitors of monoamine oxidase and decarboxylase of aromatic amino acids;5-Hydroxytryptamine and Related Indolealkylamines;1966

5. A study of 5-hydroxytryptamine formation from L-tryptophan in the brain and other tissues;Biochemical Pharmacology;1965-07