The effect of oils on the lymphatic absorption of DDT-Reference-Cited by-同舟云学术

The effect of oils on the lymphatic absorption of DDT

Published:1982-11 Issue:11 Volume:34 Page:707-710
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Palin K J¹,Wilson C G¹,Davis S S²¹,Phillips A J³¹

Affiliation:

1. Department of Physiology and Pharmacology, Medical School

2. Department of Pharmacy, University of Nottingham NG7 2RD

3. Merck, Sharp and Dohme Research Laboratories, Hoddesdon, Herts., EN11 9BU, U.K.

Abstract

Abstract Plasma concentrations of DDT were measured in conscious rats following oral administration in arachis oil, Miglyol 812 (fractionated coconut oil), liquid paraffin or as a fine suspension in water. The total absorption of DDT, calculated as the area under the plasma concentration time curve, was significantly greater for the arachis oil formulation compared to the other vehicles. In anaesthetized rats it was shown that DDT absorption was almost totally via the lymphatic system, and that lymph levels of DDT were highest following administration in arachis oil. Measurement of lymph flow showed that this enhanced absorption of DDT in the presence of arachis oil was not due to an increased flow as both arachis oil and liquid paraffin stimulated lymph production to the same extent.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/34/11/707/37622376/j.2042-7158.1982.tb06204.x.pdf

Reference19 articles.

1. Absorption of aliphatic hydrocarbons by rats

2. Bioavailability of Micronized Griseofulvin from Corn Oil‐in‐Water Emulsion, Aqueous Suspension, and Commercial Tablet Dosage Forms in Humans

3. Size of Lipoprotein Particles in the Intestinal Lymph of Rats Fed on Corn Oil, Peanut Oil, Rapeseed Oil or Canbra Oil

4. Bioavailability of phenytoin in lipid containing dosage forms in rats

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