Affiliation:
1. Nicholas Research Institute Limited, Slough, Bucks
Abstract
Abstract
The rates of solution of aspirin from aloxiprin, an aluminium derivative of acetylsalicyclic acid, in buffer solutions of pH 2–8 were found to be lower than those of aspirin B.P., particularly in the more acid buffers.
The excretion of salicylate in the urine of 11 human subjects who received aloxiprin was more delayed than that from a corresponding dose of aspirin B.P. Little difference was found in the total amount of salicylate excreted in 24 hr.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
13 articles.
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1. Antithrombotics (B01) and Antihemorrhagics (B02);Ullmann's Encyclopedia of Industrial Chemistry;2020-05-28
2. Analgesics (N02);Ullmann's Encyclopedia of Industrial Chemistry;2018-12-05
3. In-Vivo Evaluation of Different Types of Commercial Aspirin Tablets;Drug Development and Industrial Pharmacy;1989-01
4. Pharmacokinetics and metabolism of non‐steroidal anti‐inflammatory drugs;Medical Journal of Australia;1987-12
5. Aspirin and the Salicylates;Clinics in Rheumatic Diseases;1979-08