in vitro and in vivo Properties of Aloxiprin: A New Aluminium Derivative of Acetylsalicylic Acid-Reference-Cited by-同舟云学术

in vitro and in vivo Properties of Aloxiprin: A New Aluminium Derivative of Acetylsalicylic Acid

Published:1963-09 Issue:1 Volume:15 Page:56-62
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Cummings A J¹,Martin B K¹,Wiggins L F¹

Affiliation:

1. Nicholas Research Institute Limited, Slough, Bucks

Abstract

Abstract The rates of solution of aspirin from aloxiprin, an aluminium derivative of acetylsalicyclic acid, in buffer solutions of pH 2–8 were found to be lower than those of aspirin B.P., particularly in the more acid buffers. The excretion of salicylate in the urine of 11 human subjects who received aloxiprin was more delayed than that from a corresponding dose of aspirin B.P. Little difference was found in the total amount of salicylate excreted in 24 hr.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/15/1/56/37756003/j.2042-7158.1963.tb12743.x.pdf

Reference8 articles.

1. The dissolution and diffusion of aspirin in aqueous media

2. Comparison of Dissolution and Absorption Rates of Different Commercial Aspirin Tablets

3. Comparison of the Gastrointestinal Absorption of Aluminum Acetylsalicylate and Acetylsalicylic Acid in Man

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