On the Mechanism Involved in the Ability of Meptazinol to Potentiate the Effects of Sympathetic Nerve Stimulation

Author:

El-Mas M1,Goodall J1,Hughes I E1

Affiliation:

1. Department of Pharmacology, Worsley Medical and Dental Building, Universily of Leeds, Leeds LS2 9JT, Yorkshire, UK

Abstract

Abstract Mouse isolated vas deferens responded to field stimulation (0.1 Hz) with twitch responses which were abolished by ag-methyleneadenosine 5′-triphosphate (0.5 p μM) and were potentiated 2 to 3 fold by meptazinol(5–300 p μM). Exogenous adenosine 5′-triphosphate (4–30 p μM) also caused a twitch response but was unaffected by meptazinol(30 p μM) as was the response to phenylephrine. The effect of meptazinol on the electrically-induced twitch was reproducible, fast in onset, easily reversed by washing and was still seen in the presence of prazosin (1 p μM), yohimbine (1 p μM), propranolol(O.1 p μM), atropine (0.1 p μM), physostigmine (1 p μM), cocaine (1 p μM) or desmethylimipramine (0.3 p μM) indicating that the mechanism involved does not depend on adrenoceptors, cholinergic mechanisms or blockade of uptake,. Mouse isolated atria responded to stimulation (1, 2 or 5 Hz) of their sympathetic nerves via transmural electrodes with chronotropic responses which were abolished by atenolol(5 and 50 p μM) but were unaffected by ag-methyleneadenosine 5′-triphosphate (0.5 p μM). Meptazinol (100 p μM) failed to potentiate the responses. It is suggested that meptazinol potentiates the effects of the non-adrenergic non-cholinergic transmitter thought to be involved in the response of the mouse vas deferens to electrical stimulation.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference11 articles.

1. The antinociceptive effect of meptazinol depends on both opiate and cholinergic mechanisms;Bill;Br J. Pharmacol.,1983

2. A study of the actions of P1-purinoceptor agonists and antagonists in the mouse vas deferens in vitro;Blakeley;Ibid.,1988

3. The analgesic meptazinol displays a selective interaction at the μ1-opioid site;Blurton;Ibid.,1984

4. Pharmacological effects of meptazinol and its enantiomers on responses of the guinea-pig ileum and mouse vas deferens;Duchesne;J. Pharm. Pharmacol.,1984

5. Can the effect of meptazinol on the guinea-pig isolated ileum be explained by inhibition of Cholinesterase;Ennis;Ibid.,1986

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