Anti-allergic Effect of N-Acetylneuraminic Acid in Guinea-pigs-Reference-Cited by-同舟云学术

Anti-allergic Effect of N-Acetylneuraminic Acid in Guinea-pigs

Published:1990-11 Issue:11 Volume:42 Page:773-777
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Kai Hirofumi¹,Murata Yoshiyuki¹,Ishii Takayuki¹,Nishijima Sachiko¹,Murahara Koichiro¹,Ogasawara Sadanori²,Sugiyama Naokazu²,Takahama Kazuo¹,Miyata Takeshi¹

Affiliation:

1. Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862, Japan

2. Central Research Institute, MECT Co. Ltd, 1780 Kitano, Tokorozawa, Saitama 359, Japan

Abstract

Abstract The in-vivo anti-allergic effect of N-acetylneuraminic acid (NANA) in guinea-pigs passively sensitized with anti-ovalbumin rabbit serum has been studied. NANA (20 mg kg−1 i.v.) inhibited bronchial anaphylaxis and the release of histamine into bronchoalveolar lavage fluid. NANA dose-dependently inhibited heterologous passive cutaneous anaphylaxis and haemorrhaging in the passive Arthus reaction. However, it did not inhibit the release of histamine from sensitized minced lung tissue.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/11/773/37237906/j.2042-7158.1990.tb07019.x.pdf

Reference21 articles.

1. Inhibition of the anaphylactic mechanisms by sympathomimetic amines;Assem;Int. Arch. Allergy,1971

2. Effects of neuraminidase and N-acetylneuraminic acid on the adhesion of circulating granulocytes and platelets in venules;Atherton;J. Physiol.,1973

3. Bronchial hyperreactivity associated with tracheal gangliosides;Banerjee;Science,1982

4. Neuraminidase-and benzalkonium chloride-dependent inhibition of basic peptide-induced rat mast cell secretion;Coleman;Immunology Letters,1982

5. Role of the carbohydrate moiety in the antigen site(s) of human serum low-density lipoprotein;Goldstein;Biochemistry,1981

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