Chronic administration of MK-801 and the NMDA receptor: Further evidence for reduced sensitivity of the primary acceptor site from studies with the cortical wedge preparation-Reference-Cited by-同舟云学术

Chronic administration of MK-801 and the NMDA receptor: Further evidence for reduced sensitivity of the primary acceptor site from studies with the cortical wedge preparation

Published:1990-05 Issue:5 Volume:42 Page:354-355
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Beart Philip M¹,Lodge David²

Affiliation:

1. University of Melbourne, Clinical Pharmacology, Austin Hospital, Heidelberg, Victoria 3084, Australia

2. Basic Veterinary Sciences, Royal Veterinary College, London NW1 0TU, UK

Abstract

Abstract Cortical slices removed from rats pre-treated with MK-901 0.5 mg kg−1 twice a day for 7 days had reduced responses to N-methyl-D-aspartate (NMDA) relative to quisqualate and glutamate compared with control animals. Potencies of competitive (CPMP) and non-competitive (ketamine) NMDA antagonists appeared unchanged. These changes are consistent with a reduced density of NMDA receptors.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/5/354/37238111/j.2042-7158.1990.tb05426.x.pdf

Reference5 articles.

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3. A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists;Lodge;Br J. Pharmacol.,1988

4. Subchronic administration of MK-801 in the rat decreases cortical binding of [3H] D-AP5, suggesting down-regulation of the cortical N-methyl-D-asparatate receptor;Manallack;Neuroscience,1989

5. Receptor site topographies for phencyclidine-like drugs: predictions from quantitative comformational, electrostatic potential, and radioreceptor analyses;Manallack;Mol. Pharmacol.,1989

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