The Effect of Solubilized Water on the Size and Shape of Lecithin Micelles in an Apolar Solvent-Reference-Cited by-同舟云学术

The Effect of Solubilized Water on the Size and Shape of Lecithin Micelles in an Apolar Solvent

Published:1990-09 Issue:9 Volume:42 Page:601-605
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Evans Richard M¹,Attwood David²¹,Chatham Sarah M³¹,Farr Stephen J¹

Affiliation:

1. Welsh School of Pharmacy, University of Wales College of Cardiff, Cardiff CF1 3XF

2. Pharmacy Department, The University, Oxford Road, Manchester M13 9PL

3. Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK

Abstract

Abstract The changes in the size and shape of the micelles of soya lecithin in trichlorotrifluoroethane following the solubilization of increasing quantities of water have been examined by dynamic and static light scattering and viscometric techniques. Micelles in systems with water/lecithin molar ratios, R, of less than 2.6 were oblate and exhibited no significant changes in asymmetry or aggregation number with changes in the amount of solubilized water. Spherical micelles were evident in systems with R = 2.6 whereas prolate micelles were present in solutions of higher water content (3.5 ≤ R ≤ 5.2). An increase of R in these systems caused a decrease in the axial ratio and an increase in the aggregation number of the micelle.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/9/601/37238457/j.2042-7158.1990.tb06615.x.pdf

Reference24 articles.

1. Optimized inhalation aerosols. I. The effects of spherical baffle size and position upon the output of several pressurized nonaqueous suspension formulations;Byron;Pharm. Res.,1989

2. Comparison of output particle size distributions from pressurized aerosols formulated as solutions or suspensions;Dalby;Ibid.,1988

3. Surfactants in nonpolar solvents: aggregation and micellization;Eicke,1980

4. On the stability of micelles in apolar media;Eicke;J. Colloid Interface Sci.,1974

5. Interactions in and catalysis by micelles in nonaqueous solvent and in liquid crystalline phases;Fendler,1975

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