The in-situ absorption of antipyrine as a measure of intestinal blood flow in Fluosol-DA haemodiluted rats-Reference-Cited by-同舟云学术

The in-situ absorption of antipyrine as a measure of intestinal blood flow in Fluosol-DA haemodiluted rats

Published:1990-07 Issue:7 Volume:42 Page:511-512
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Shrewsbury Robert P¹,White Lisa G²

Affiliation:

1. School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599

2. College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA

Abstract

Abstract The effect of moderate Fluosol-DA haemodilution on intestinal blood flow has been investigated in the rat. Antipyrine in-situ intestinal absorption is blood flow limited, and did not alter 0.5, 24, 48, or 72 h after haemodilution with 40 mL kg−1 Fluosol. Thus the intestinal blood flow rate is maintained as part of the physiological response to ensure adequate perfusion of the vital organ.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/42/7/511/37238214/j.2042-7158.1990.tb06608.x.pdf

Reference19 articles.

1. Duodenal calcium absorption in rats with transfusion of Fluosol-DA: rapid action of 1,25-dihydroxyvitamin D3;Aso,1979

2. The intraluminal administration of Fluosol-43 (FC-43) to the ischemic intestine;Baba,1979

3. Ex-vivo perfusion of surgically removed organs;Baba;Biomat. Art. Cells Art. Org.,1988

4. Blood substitutes and the cardiovascular system;Biro;Ibid.,1988

5. The effect of hemodilution with fluorocarbon or dextran on regional myocardial flow and function during acute coronary stenosis in the pig;Biro;Am. J. Cardiovasc. Path.,1987

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1. Oxygenated perfusion for liver preservation: a perfluorodecalin-UW emulsion is not feasible;Transplantation Proceedings;1998-11

2. Absorption of D-glucose in the rat studied using in situ intestinal perfusion: A permeability-index approach;Pharmaceutical Research;1997

3. KINETIC-ANALYSIS OF THE DRUG PERMEATION PROCESS ACROSS THE INTESTINAL EPITHELIUM;Pharmaceutical Research;1994

4. Acute Effects of Moderate Fluosol-DA Hemodilution on Hepatic Microsomal and Nonmicrosomal Metabolism in Rats;Biomaterials, Artificial Cells and Immobilization Biotechnology;1992-01