The presence of mucosa reduces the contractile response of the guinea-pig urinary bladder to substance P-Reference-Cited by-同舟云学术

The presence of mucosa reduces the contractile response of the guinea-pig urinary bladder to substance P

Published:1987-08 Issue:8 Volume:39 Page:653-655
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Maggi Carlo Alberto¹,Santicioli Paolo¹,Parlani Massimo²,Astolfi Mara²,Patacchini Riccardo¹,Meli Alberto¹

Affiliation:

1. Pharmacology Department, A. Menarini Pharmaceuticals, Via Sette Santi 3, Florence

2. C.R.F. Pomezia, Rome, Italy

Abstract

Abstract The contractile response to substance P in-vitro is greater in strips of guinea-pig bladder freed of mucosa than in normal strips, while the response to field stimulation, histamine or KCl is unaffected by the presence of mucosa. Substance P has no inhibitory effect on histamine-induced contractions of the guinea-pig bladder. These findings support the possibility that the presence of mucosa may reduce accessibility of substance P to the muscle layer.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/39/8/653/37544673/j.2042-7158.1987.tb03447.x.pdf

Reference13 articles.

1. Novel Pharmacology of Substance K-Binding Sites: a Third Type of Tachykinin Receptor

2. Multiple tachykinin binding sites in hamster, rat and guinea-pig urinary bladder

3. Desensitization of the guinea-pig urinary bladder by the enantiomers of adenylyl 5′-(β,γ-methylene)-diphosphonate and by substance P

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